COntrolled REcombination in plant breeding (CORE)

COntrolled REcombination in plant breeding (CORE)


WR-cap TU




Landbouw, Water, Voedsel>Sleuteltechnologieën LWV>Biotechnologie en Veredeling






When during plant breeding disease resistances are being introgressed from wild donors into elite lines, many undesired traits, so-called linkage drag, come along. For removal of these undesired traits, recombination in the respective chromosome on (crossover) is needed between the resistance gene and the linkage drag. However, breeders cannot influence the positions of crossovers. Therefore, they make large populations, hoping for a lucky shot. It would accelerate breeding significantly, if breeders could control the positions of crossovers. This is the first aim of the project: targeted crossovers.

Sometimes resistance genes reside in chromosomal rearrangements, such as inversions. Homologous chromosomes do not show crossovers in inversions. If a resistance gene is located in an inversion, it is unbreakably connected to linkage drag in that inversion. This problem has been known for decades but has never been solved. Therefore, the second aim of the project is reversion of inversions, after which recombination can be expected to occur in that area.

Doel van het project

The project aims at supporting plant breeding, especially for introgression of disease and pest resistances into crops, for a more durable primary production that requires less pesticides.

Relatie met missie (Motivatie)

Conventional plant breeding is a rather slow process, especially because crossovers between parental chromosomes occur at positions that are not controlled by the plant breeder. This slows down the breeding process and efficiency considerably. This project aims at targeted crossover, and also at reversion of inversion, thus allowing crossovers at positions where earlier crossovers could not occur.

Geplande acties

1. A method for targeted recombination, applicable by plant breeding companies;
2. A method for reversion of inversions, applicable by plant breeding companies.