Lactastic

Lactastic

Organisatie-onderdeel

TKI AF

Projectcode

LWV20043

MMIP

Landbouw, Water, Voedsel>D. Gewaardeerd, gezond en veilig voedsel>D2. De consument, duurzame en gezonde voeding in een groene leefomgeving

Startdatum

01/01/21

Einddatum

31/12/26

Samenvatting

70% van de wereldbevolking is Lactase Non-Persistent (LNP). Dit betekent dat ze op basis van hun genetische opmaak het enzym lactase niet aanmaken, wat normaal gesproken zorgt voor de vetering van lactose. LNP komt vooral voor in Azië en grote delen van Afrika. Aan de hand van deze studie wil men inzicht krijgen in welke mate LNP-personen lactose kunnen verdragen en verteren. Op deze manier kan juist de bevolking in ontwikkelingslanden toch profiteren van alle nutriënten die zuivel rijk is.

Doel van het project

The dairy industry and scientific world are very much interested in milk proteins and the beneficial health effects they exert in different target groups. This is also reflected by a number of pending and approved TKI-projects (e.g. LWV19131, LWV19150 and AF-18012). Currently, none of the dairy related TKI-projects focus on lactose. This TKI proposal can in increase the impact of these projects by allowing more people to have access to dairy products without experiencing gastro-intestinal complaints.
With this study we want to build on to the available scientific knowledge about dairy, in particular about the nutritional role of lactose. Lactose may have beneficial health effects, potentially even in those who are not able to digest it (e.g. through the gut microbiota). As such, dairy plays an integral role in a healthy and safe diet, also among LNP individuals.
It is of great importance that current non-dairy consumers are informed about these benefits as well. Since the prevalence of LNP is relatively high in Asia and Africa there is much to gain. Especially in those regions where affordable nutrition plays an important role, low-cost nutrient-rich dairy products can vastly contribute to the nutritional health status of the population. In Western countries, where LNP prevalence is relatively low, the trend in consuming lactose-free products is increasing. This study will help to create awareness on the health benefits of dairy and the valorization of lactose as a milk intrinsic sugar, enabling consumers to make conscious and well-substantiated healthy diet choices. On top of that, this study will increase the valorization of milk components and thus contributes to the value creation for Dutch farmers and accompanying industry.

Relatie met missie (Motivatie)

This project potentially has a huge societal impact, as the outcomes of the study will affect more than 70% of the world population. With this study we aim to show that lactose consumption, by lactase non-persistent (LNP) individuals, supports the growth of lactose-digesting bacteria in the colon, which enhances colonic lactose processing and possibly results in the reduction of intolerance symptoms and the production of beneficial metabolites. Since the prevalence of LNP is relatively high in Africa and Asia there is much to gain. Especially in those regions where affordable nutrition plays an important role, low-cost nutrient-rich dairy products can vastly contribute to the nutritional health status of the population. In Western countries, where LNP prevalence is relatively low, the trend in consuming lactose-free products is increasing. This study will help to create awareness on the health benefits of dairy and the valorization of lactose as an intrinsic sugar, enabling consumers to make conscious and well-substantiated healthy diet choices.

Geplande acties

Deliverables in terms of content:
- Insights on the colonic microbial adaptation induced by repetitive consumption of an increasing dose of dietary lactose by microbiota shotgun sequencing.
- Insights on dose-response effect of lactose that is needed for colonic adaptation.
- The shotgun metagenomics approach also gives insight in genetic functional potential of the populations as it shows semiquantitative portrait of genes, gene groups or metabolic pathways in the microbial community.
- The changes in lactose intolerance functional outcomes after repetitive consumption of an increasing dose of dietary lactose, such as GI discomfort, microbial lactase activity, exhaled hydrogen (hydrogen breath test) and eventually fecal metabolomics
- Shotgun metagenomics in combination with fecal metabolomics, targeted and untargeted, could lead to new insights into what beneficial role lactose could play in adult (gut) health in LNP individuals.

Deliverables in terms of results:
- A scientific publication on health effects of lactose in lactose intolerant individuals
- Education of healthcare professionals (e.g. dieticians) on the benefits of lactose; by organizing a FC Institute webinar, or a presentation in an international conference(s)
- Non-scientific publication in newsletter of ZuivelNL and Voeding Magazine (NZO)
- Non-scientific article on Melkweb; a platform for member-dairy farmers of FC

Naam projectleider

Marjon Navarro
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