PhenFlex-based resilience as measure for health effects of diet

PhenFlex-based resilience as measure for health effects of diet

Organisatie-onderdeel

TKI AF

Projectcode

AF16035

MMIP

Landbouw, Water, Voedsel>D. Gewaardeerd, gezond en veilig voedsel>D2. De consument, duurzame en gezonde voeding in een groene leefomgeving

Startdatum

01/01/17

Einddatum

31/12/21

Samenvatting

Het meten van gezondheidseffecten van voeding en dieet is nog altijd een obstakel in de innovatieve pijplijn van vele voedingsbedrijven in Europa. Het is lastig om de gezondheidseffecten van een dieet of van ingrediënten te kunnen demonstreren. Om het effect te kunnen laten zien, is het noodzakelijk om een verandering in biomarkers weer te geven na een dieet.

Om de multi-target rol van voeding in het lichaam te erkennen, is het doel van dit project om het concept van verbetering van fenotypische flexibiliteit door voedingsinterventie te onderbouwen. Robuust bewijs voor dit concept en de daarmee samenhangende opkomst van nieuwe biomarkers zal naar verwachting de acceptatie van fenotypische flexibiliteit als gezondheidsvoordeel op zich door regelgevende autoriteiten zoals de EFSA verder bevorderen. Het doel van dit project is om proof-of-concept vast te stellen voor de toepassing van het challenge test-concept voor de wetenschappelijke onderbouwing van gezondheidsvoordelen van een optimale voeding in een gecontroleerde interventionele setting (studie 1)

Bovendien zal in een tweede studie de fenotypische flexibiliteit worden gemeten bij een zieke populatie van COPD-patiënten voor en na hun longrevalidatie (een multidimensionale benadering). Deze studie zal een eerste inzicht geven in de toepasbaarheid en geschiktheid van het veerkrachtconcept in een populatie met suboptimale gezondheidskenmerken (Spruit et al, Eur Respir J. 2016). De resultaten van de challenge-testresultaten zullen worden vergeleken met de resultaten van controles om een indicatie te vinden van verbetering van de veerkracht bij COPD-patiënten na gepersonaliseerde revalidatie (pilot-studie 2).

Doel van het project

Objectives of the study are:
• To demonstrate that a healthy or optimal diet in an intervention study can improve “metabolic age” and “metabolic stress”, which are composite biomarkers by quantifying phenotypic flexibility, within a healthy population. These composite markers validate previous findings from other intervention studies using phenotypic flexibility and could be the next generation biomarkers.
• To show additional advantages of personalization / tailoring of dietary recommendations over general dietary recommendations. PhenFlex-2 delivers the scientific evidence that a healthy diet is beneficial for your health specially when this is tailored to the (nutritional) needs of a person.
• To encourage acceptation of the approach by the international scientific community by publications in peer-reviewed journals and discussions with regulatory authorities.
• To learn more about other new biomarkers, (DIY) methods and study-designs that in the future can be used to substantiate health effects of food and nutrition.

Relatie met missie (Motivatie)

The measurement of health effects of food and diet remains a hurdle in the innovation pipeline of many food companies in Europe. Nutrition science has difficulty to demonstrate specific health-beneficial effects related to diet or dietary ingredients such as probiotics. PhenFlex represents a new avenue of providing evidence for building health claims and strengthens the importance of resilience-thinking in health research. Robust proof for this concept and the related emergence of new biomarkers is expected to further promote acceptance of phenotypic flexibility as health benefit in itself by regulatory authorities like the EFSA. A next generation health claim based on the concept of resilience could contribute to making healthy nutrition available to the consumer. Furthermore, within this project we will also evaluate the effect of personalised nutrition based on this resilience concept. The expectation is that when consumers are being confronted with feedback on their health (by means of phenotypic flexibility evaluation) as well as on their eating behaviour, it will become easier to make the healthy choice the easy choice. Therefore, the research from the public private partnership “PhenFlex-based resilience as measure for health effects of diet” contributes to mission D2 healthy nutrition an easy choice

Being resilient is a great value for any dynamic system and a prerequisite to maintain sustainable system performance in increasingly complex, demanding and connected societies. Health is no exception to this. The Netherlands, and TNO as recognized party, is a frontrunner in resilience thinking and this project will contribute to strengthen this position.

Geplande acties

DELIVERABLES (D) & MILESTONES (M)
D1. design of a biomarker for “metabolic age” and “metabolic stress” as primary read-out for intervention studies and agreed by all partners of the consortium. (June 2017)
D2. approved METC protocol agreed by all partners of the consortium. (August 2017)
D3. approved METC protocol for Ciro study. (August 2017)
M1. Completion of the intervention study. (July 2018)
M2: Completion of the intervention study for Ciro study. (January 2018)
D4. Data Analysis Plan agreed by all partners of the consortium. (October 2018)
D5. Two scientific articles describing results of the human intervention study. (April 2020)
D6. An opinion article that proposes an acceptability strategy for the concepts and application of phenotypic flexibility in collaboration with ILSI and stakeholders from different meetings. (April 2020)

OUTPUT (up to and including 2020)
O1. 13 Scientific publications
O2. >14 Conference publications (poster/presentation)
O3. >2 Spin-offs
O4. 2 New projects with industrial partners
O5. 3 Non-scientific presentations (interviews)

Naam projectleider

Suzan Wopereis