Transcriptional networks up- and downstream of the negative regulators of plant immunity DMR6 an DLO1
The regulatory mechanisms by which the plant susceptibility genes DMR6 and DLO1 control plant immunity are unknown. In this project the transcriptional regulation of the DMR6/DLO1 genes and the altered expression of plant immunity genes in the Arabidopsis dmr6 and dlo1 mutants will be studied. It is expected that important regulatory mechanisms will be revealed that can be utilized to design new strategies for improving disease resistance in crops. This is relevant for society as new methods to protect crops from diseases and produce food in a sustainable way are highly demanded.
The aim of this project is to gain insight into the regulation of the DMR6 and DLO1 genes and altered expression of plant immunity genes in the dmr6 and dlo1 mutants. Such knowledge is important to understand which immune responses are triggered in the resistant mutants, and how DMR6 and DLO1 control this in wild-type plants. Understanding the molecular mechanisms of dmr6 and dlo1-mediated resistance is essential for their optimal utilization in resistance breeding, and will be important to find the right balance between the positive resistance-inducing effects and negative side-effects on plant